Efektivitas Suplementasi Zink Dan Sinbiotik Dalam Mendukung Kesehatan Lansia: Tinjauan Sistematis
DOI:
https://doi.org/10.32382/medkes.v20i1.1459Kata Kunci:
zink, sinbiotik, lansia, respon imunAbstrak
Semakin berkembangnya populasi lansia, maka terjadi peningkatan angka harapan hidup. Hal ini membawa tantangan besar terkait kesehatan mereka, terutama dalam menjaga fungsi imun dan pencernaan. Zink dan sinbiotik (kombinasi probiotik dan prebiotik) menjadi dua intervensi gizi yang menjanjikan dalam mendukung kesehatan lansia. Artikel ini mengulas efek dari zink dan sinbiotik, serta kombinasi keduanya terhadap kesehatan lansia, dengan fokus utama pada respon imun, sarcopenia, dan kelelahan. Berdasarkan tinjauan sistematis berasal dari literatur PubMed, Scopus, dan Google Scholar dari 600 artikel menjadi 10 artikel terpilih (2017-2024) khusus uji terkontrol acak menggunakan Cochrane Risk of Bias Tool secara algoritma PRISMA . Menunjukkan bahwa suplementasi zink memiliki potensi untuk meningkatkan sistem kekebalan tubuh dan mengurangi peradangan, yang berkontribusi terhadap peningkatan kualitas hidup lansia. Sementara itu, sinbiotik terbukti efektif dalam memperbaiki kesehatan usus, mengatasi disbiosis mikrobiota yang umum terjadi pada lansia, dan meningkatkan keseimbangan mikrobiota usus yang mendukung fungsi imun. Zink membantu meningkatkan daya tahan tubuh dan fungsi otak, sementara sinbiotik memperbaiki kesehatan pencernaan dan menurunkan peradangan. Bila dikombinasikan, keduanya memberikan efek yang lebih kuat dan saling melengkapi dalam menjaga kesehatan lansia secara menyeluruh. Dibutuhkan penelitian lebih lanjut dengan desain yang lebih kuat untuk memvalidasi manfaat keduanya serta rekomendasi klinis untuk intervensi gizi pada lansia dapat diperluas berdasarkan temuan ini.
Kata Kunci: zink, sinbiotik, lansia, respon imun
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