Tinjauan Hasil Pemeriksaan NS1 Dan IgG/IgM Dengue Metode Imunokromatografi Terhadap Hasil Pemeriksaan Total Jumlah Dan Indeks Trombosit Pada Penderita Demam Dengue
DOI:
https://doi.org/10.32382/medkes.v20i1.1439Kata Kunci:
Demam Berdarah Dengue, IgG IgM Dengue, Dengue NS1, Jumlah Trombosit, Indeks TrombositAbstrak
Demam dengue berisiko menimbulkan sindrom syok dengue yang dapat menyebabkan kematian jika tidak didiagnosis dan ditangani secara dini. Selain melakukan anamnesis dan pemeriksaan fisik diperlukan pemeriksaan laboratorium. Pemeriksaan laboratorium yang dapat dilakukan antara lain pemeriksaan NS1 dengue, IgG IgM dengue, hitung total jumlah dan indeks trombosit. Penelitian ini bertujuan untuk mengetahui korelasi antara hasil pemeriksaan NS1 dan IgG IgM dengue terhadap hasil pemeriksaan total jumlah dan indeks trombosit (MPV, PDW, P-LCR, dan PCT) pada penderita demam dengue. Penelitian ini merupakan penelitian korelatif dengan pendekatan cross sectional analitik, menggunakan teknik pengambilan sampel purposive sampling dan diperoleh sebanyak 40 sampel yang memenuhi kriteria penelitian, yang dilaksanakan di Laboratorium Patologi Klinik Rumah Sakit Pendidikan Tinggi Negeri Universitas Hasanuddin Makassar pada 1 Desember 2024 sampai 28 Februari 2025. Hasil penelitian menunjukkan bahwa terdapat hubungan yang bermakna antara hasil pemeriksaan IgG dengue terhadap pemeriksaan total jumlah trombosit p=0.032 (p<0.05) dan PDW p=0.031 (p<0.05), sedangkan tidak terdapat hubungan yang bermakna terhadap hasil pemeriksaan PCT p=0.788 (p>0.05). Untuk hasil pemeriksaan IgM dengue dan NS1 dengue masing-masing didapatkan tidak terdapat hubungan yang bermakna terhadap pemeriksaan total jumlah trombosit p=0.565 p=0.624 (p>0.05), PDW p=0.728 p=0.188 (p>0.05), dan PCT p=0.841 p=0.454 (p>0.05). Hasil pemeriksaan MPV dan P-LCR menunjukkan hasil yang konstan, sehingga tidak dilakukan uji statistik. Disimpulkan bahwa pemeriksaan total jumlah trombosit dan indeks trombosit PDW dapat menjadi biomarker laboratorium potensial untuk skrining, diagnosis, dan pemantauan pasien terinfeksi dengue berdasarkan hasil pemeriksaan IgG dengue.
Kata Kunci: Demam Dengue; IgG IgM Dengue; Indeks Trombosit; Jumlah Trombosit; NS1 Dengue
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