Evaluasi Keamanan Sirup Batuk Anak Melalui Deteksi Dietilen Glikol: Safety Evaluation of Children's Cough Syrup Through Detection of Diethylene Glycol

Andi Ardiansyah Arifin; Megawati; Nurjannah; Syamsu Nur

doi:10.32382/mf.v21i1.1255

Penulis

Andi Ardiansyah Arifin Universitas Almarisah Madani, Makassar, Indonesia
Megawati Universitas Almarisah Madani, Makassar, Indonesia
Nurjannah Universitas Almarisah Madani, Makassar, Indonesia
Syamsu Nur Universitas Almarisah Madani, Makassar, Indonesia

DOI:

https://doi.org/10.32382/mf.v21i1.1255

Kata Kunci:

Sirop, Dietilen Glikol, FT-IR, Kromatografi Lapis Tipis

Abstrak

A recent report highlighted cases of contamination in children's cough syrup containing diethylene glycol, which poses potential health risks for children. This study aims to identify the presence of diethylene glycol in various children's cough syrups sold in Makassar City using Thin Layer Chromatography (TLC) and FT-IR Spectroscopy methods. A total of 9 samples of children's cough syrup from three different brands, each originating from three batches, were analyzed in this study. The TLC analysis results showed significant differences between the samples and the standard. The Rf values of the samples ranged from 0.72 to 0.85, while the Rf value of the diethylene glycol standard was recorded at 0.41. Additionally, FT-IR analysis, based on the wave numbers and intensity of the spectra, indicated that the sample spectra did not match those of the diethylene glycol standard. Based on the evaluation of all children's cough syrup samples using these two methods, no profiles consistent with the characteristics of diethylene glycol were detected.

Kejadian kasus kontaminasi sirup obat batuk anak dengan kandungan dietilen glikol, yang berpotensi membahayakan kesehatan anak baru-baru ini dilaporkan. Penelitian ini bertujuan untuk mengidentifikasi keberadaan dietilen glikol pada sejumlah sirup obat batuk anak yang dijual di Kota Makassar, menggunakan metode Kromatografi Lapis Tipis (KLT) dan Spektroskopi FT-IR. Sebanyak 9 sampel sirup obat batuk dari tiga merek dagang berbeda, masing-masing berasal dari tiga batch, digunakan dalam penelitian ini. Hasil analisis KLT menunjukkan adanya perbedaan signifikan antara sampel dan standar. Nilai Rf pada sampel berkisar antara 0,72 hingga 0,85, sedangkan nilai Rf standar dietilen glikol tercatat sebesar 0,41. Selain itu, analisis dengan FT-IR, berdasarkan bilangan gelombang dan intensitas spektrumnya, juga menunjukkan bahwa spektrum sampel tidak sesuai dengan standar dietilen glikol. Berdasarkan evaluasi terhadap seluruh sampel sirup obat batuk anak menggunakan kedua metode ini, tidak ditemukan profil yang sesuai dengan karakteristik dietilen glikol.

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