Peningkatan Kelarutan Ketoprofen Dalam Bentuk Mikropartikel Dengan Metode Emulsification-Ionic-Gelation Menggunakan Polyvinylprrolidone (PVP) Dan Tripolifosfat(TPP)

Nurul Fitri Dirgahayu Yahya; Santi Sinala; Hendra Stevani

doi:10.32382/mf.v20i2.1006

Penulis

Nurul Fitri Dirgahayu Yahya Poltekkes Kemenkes Makassar
Santi Sinala Poltekkes Kemenkes Makassar
Hendra Stevani Poltekkes Kemenkes Makassar https://orcid.org/0000-0002-4185-7188

DOI:

https://doi.org/10.32382/mf.v20i2.1006

Kata Kunci:

Ketoprofen, emulsification-ionic-gelation, polivinylprrolidone, tripolifosfat, kelarutan

Abstrak

Improving Solubility of Ketoprofen In Microparticle Form By Emulsification-Ionic-Gelation Method Using Polyvinylprrolidone (PVP) And Tripolyphosphate (TPP)

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that has low solubility in water, thus inhibiting drug absorption into the body. This study aims to increase the solubility of ketoprofen using emulsification-ionic-gelation method with PVP as polymer and TPP as crosslinker. Microparticles were prepared using three formulas with variations in TPP pH (2, 4, and 6). Characterization was performed using Scanning Electron Microscopy (SEM) and solubility test using UV-Vis spectrophotometer. SEM results showed a gradual decrease in particle size from pH 2, 4, and 6. Solubility tests showed a two-fold increase in solubility compared to untreated ketoprofen, with the highest solubility at pH 6. The combination of PVP and TPP in the emulsification-ionic-gelation method effectively increased solubility.

Ketoprofen merupakan obat antiinflamasi nonsteroid (OAINS) yang memiliki kelarutan rendah dalam air, sehingga menghambat absorpsi obat ke dalam tubuh. Penelitian ini bertujuan untuk meningkatkan kelarutan ketoprofen menggunakan metode emulsification-ionic-gelation dengan PVP sebagai polimer dan TPP sebagai crosslinker. Mikropartikel dibuat menggunakan tiga formula dengan variasi pH TPP (2, 4, dan 6). Karakterisasi dilakukan menggunakan Scanning Electron Microscopy (SEM) dan uji kelarutan menggunakan spektrofotometer UV-Vis. Hasil SEM menunjukkan penurunan ukuran partikel secara bertahap dari pH 2, 4, dan 6. Uji kelarutan menunjukkan peningkatan kelarutan dua kali lipat dibandingkan ketoprofen tanpa perlakuan, dengan kelarutan tertinggi pada pH 6. Kombinasi PVP dan TPP dalam metode emulsification-ionic-gelation efektif meningkatkan kelarutan

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